Quote: Adiposity causes inflammation of the hypothalamus

Adiposity is associated with chronic low-grade systemic inflammation and increased inflammation in the hypothalamus, a key structure in feeding behavior.

Obesity-mediated inflammation may damage the brain circuit that regulates food intake. Brain Res. 2011 Feb 10;1373:101-9. 

In other words, excess fatty tissue in obesity harms the hypothalamus, the brain structure that regulates feeding behaviour, and makes it more difficult to control overeating. Through inflammation, excess fatty tissue takes control. The solution, a non-inflammatory diet such as the Paleo diet. 

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